Dr Giancarlo Forte

Giancarlo brings expertise in mechanosensing and advanced in vitro disease models to REACT.

His group has been working at the forefront of the field for more than a decade. They revealed how the mechanical stress associated with ECM remodelling in the diseased heart affects the mRNA alternative splicing in cardiomyocytes. This happens through the regulation of the subcellular localization of RNA binding proteins. He is excited to contribute to REACT by challenging the hypothesis that similar events might occur during the early phases of the activation of cardiac fibroblasts and the establishment of heart fibrosis.

Giancarlo's work in REACT is driven by the dream of designing RNA-based drugs able to revert cardiac fibrosis, a condition which accompanies most of the cardiac diseases and currently has no treatment. He sees REACT as a revolutionary project bringing together extraordinary scientists and with a clear goal. For many years, Giancarlo's research has been focused on the molecular basis of diseases, and now it is time to use the knowledge acquired during those years to benefit patients.