Developing manganese-enhanced MRI as a translational biomarker of cardiac regeneration
Effective translation of the therapeutics developed in REACT will require in vivo monitoring of safety and efficacy. MRI, CT and ultrasound have been used to follow cardiac function in clinical and preclinical trials of cell therapies but have not been …
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Genetic tracing and topography of spontaneous and stimulated cardiac regeneration in mice
Ilaria Secco …
Proregenerative MicroRNAs to Repair the Damaged Heart
King's College London …
Mapping the heart proteome and lipidome
Beyza Guve …
Professor Paul Riley
Paul is BHF Professor of Regenerative Medicine and Director of the Institute of Developmental and Regenerative Medicine at the University of Oxford. His research interests span cardiovascular developmental biology and modelling congenital heart disease, …
Monitoring regenerative pathway activation in vivo
REACT will generate a range of therapies able to activate endogenous cardiac regeneration and cardiomyocyte proliferation. However, the lack of reliable in vivo methods for tracking cell cycle makes it challenging to study mechanisms and mediators of …
Counteracting cardiac fibrosis through LNP-mediated microRNA delivery
Fibrosis underpins all forms of cardiac disease. Cardiac fibrosis ensues from an over-activation of cardiac fibroblasts upon cardiac injury and their differentiation into myofibroblasts. Fibroblast activation is initially of protective nature, but …
Dr Camilla Olianti
Camilla is an MSCA Postdoctoral Fellow in Mauro Giacca’s research group at King’s College London. Within REACT, Camilla's role is to investigate the structural features of cardiac regeneration in 3D at high resolution. Camilla uses advanced optical …