New medicines to fix failing hearts
Heart failure affects almost one million people in the UK and more than 65 million people around the world, with heart attacks the main cause. No current treatment is able to regenerate the heart after a heart attack. Our growing community brings together …
Professor Clare Blackburn
Clare is Professor of Tissue Stem Cell Biology at the University of Edinburgh and an experienced leader in training and dissemination across biological sciences and regenerative medicine. Clare has a strong interest in public engagement and is the …
Dr Filipa Simões
Filipa is Co-director of the Oxford Organoid Hub and a Group Leader and British Heart Foundation Intermediate Basic Science Fellow at the Institute of Developmental and Regenerative Medicine, University of …
The dark genome in cardiovascular medicine
Despoina Kesidou …
Exploring long non-coding RNAs as therapeutic targets
Gayan Balasooriya …
Screening for drivers of lymphangiogenesis
Christophe Ravaud …
Understanding programmed cellular synthesis of resorbable scar after acute myocardial infarction
Philip Langer …
Developing a small molecule drug-controllable system in a clinical AAV vector for cardiac gene therapy
Adeno-associated virus (AAV) vectors typically deliver a genetic information under a promoter that is either ubiquitous or cell-specific, but with no other means of control. Controllable systems, which can be used to turn off or titrate gene expression or …
Computationally identifying conserved drivers of cardiac repair
The injured heart undergoes coordinated phases of inflammation, proliferation and maturation, comprising interconnected biological processes that determine reparative capacity. These include regeneration of lost myocardium, recruitment and activation of …