Proregenerative MicroRNAs to Repair the Damaged Heart
Camilla Olianti …
The Medical Research Council/British Heart Foundation Centre of Research Excellence in Advanced Cardiac Therapies (REACT)
University of Edinburgh …
New medicines to fix failing hearts
Heart failure affects almost one million people in the UK and more than 65 million people around the world, with heart attacks the main cause. No current treatment is able to regenerate the heart after a heart attack. Our growing community brings together …
Clinical translation
A comprehensive array of pre-clinical models will be utilised to test therapeutic leads generated by REACT. Existing targets will be fast tracked for safety and efficacy assessment in models of chronic heart failure conditions, and then prioritised for …
Professor Ajay Shah
Ajay is BHF Chair of Cardiology and Executive Dean of the Faculty of Life Sciences & Medicine at King's College London, and an Honorary Consultant Cardiologist at King’s College Hospital. Ajay has a long-standing track record of innovative research in the …
Cardiac delivery
We aim to achieve cardiac-specific targeting of vectors and nanoparticle-delivered nucleic acid medicines to minimise adverse effects and allow for effective, inducible and/or regulated expression of single or multiple target therapeutic nucleic acids. …
Governance
The MRC/BHF CoRE in Advanced Cardiac Therapies began on 1 January 2025, with a duration of 14 years. Funding has been secured for an initial 7 year period. An experienced leadership team are responsible for delivering CoRE research and impact. Day-to-day …
Dr Roman Fischer
Roman is an Associate Professor at the Target Discovery Institute and Centre for Medicines Discovery in the Nuffield Department of Medicine at the University of Oxford. Roman leads two proteomics-focussed laboratories: the Discovery Proteomics Facility …
Dr Camilla Olianti
Camilla is an MSCA Postdoctoral Fellow in Mauro Giacca’s research group at King’s College London. Within REACT, Camilla's role is to investigate the structural features of cardiac regeneration in 3D at high resolution. Camilla uses advanced optical …
Opportunities
Our scientific mission and collaborative approach are both ambitious. Developing new therapies relies on the expanding knowledge and skills of many individuals and teams. Bespoke opportunities to nurture careers, share practice and forge new partnerships …