Professor Steve Pollard
Steve is a group leader at the University of Edinburgh Institute for Regeneration and Repair. …
Dr Rebeca Diaz-Vazquez
Rebeca is a postdoctoral researcher at the University of Edinburgh. …
Dr Annalisa Bettini
Annalisa is a research fellow at University College London. …
Dr Zhiping Feng
Zhiping is a research fellow at University College London. …
Identifying early response RNA binding proteins in cardiac fibrosis
The biomechanical stress associated with pathological heart extracellular matrix (ECM) remodelling modifies the transcriptional and post-transcriptional landscape of cardiac cells. Post-transcriptional events such as alternative splicing (AS), RNA …
Developing manganese-enhanced MRI as a translational biomarker of cardiac regeneration
Effective translation of the therapeutics developed in REACT will require in vivo monitoring of safety and efficacy. MRI, CT and ultrasound have been used to follow cardiac function in clinical and preclinical trials of cell therapies but have not been …
Screening for drivers of lymphangiogenesis
Myocardial infarction (MI) induces cardiac muscle death and its subsequent replacement by a non-contractile fibrotic scar, which leads to heart failure. Current treatments restore blood flow and assist with cardiac workload. However, none are regenerative …
Monitoring regenerative pathway activation in vivo
REACT will generate a range of therapies able to activate endogenous cardiac regeneration and cardiomyocyte proliferation. However, the lack of reliable in vivo methods for tracking cell cycle makes it challenging to study mechanisms and mediators of …
Modulating extracellular matrix composition to facilitate heart regeneration
After a heart attack (myocardial infarction, MI) the heart forms stiff scars made of collagen. These scars are stabilised by strong chemical bonds called cross-links, which make them hard to break down and hinder healing. Zebrafish hearts, unlike adult …
Mapping the heart proteome and lipidome
Heart disease is a complex condition that necessitates targeted drug delivery to specific cell types. To achieve this, a comprehensive understanding of the cell surface proteome and its receptor landscape is crucial. While RNA therapeutics hold immense …