Dr Gang Li
Gang Li is a researcher at King's College London. …
Developing a small molecule drug-controllable system in a clinical AAV vector for cardiac gene therapy
Adeno-associated virus (AAV) vectors typically deliver a genetic information under a promoter that is either ubiquitous or cell-specific, but with no other means of control. Controllable systems, which can be used to turn off or titrate gene expression or …
Exploring long non-coding RNAs as therapeutic targets
Our goal is to identify novel long RNAs (lncRNAs) that regulate heart muscle cell growth. We utilise bioinformatic analysis, high throughput screening assays, characterisation of molecular mechanisms, long RNA manipulation in a lab in vivo model of heart …
Understanding programmed cellular synthesis of resorbable scar after acute myocardial infarction
After myocardial infarction (MI), neonatal mice heal through a process of regeneration. An intermediate step is the formation of a collagen-rich but fully resorbable 'patch'. This is distinct from the permanent scar which is made by the adult mouse and …
Professor Steve Pollard
Steve is a group leader at the University of Edinburgh Institute for Regeneration and Repair. …
Dr Rebeca Diaz-Vazquez
Rebeca is a postdoctoral researcher at the University of Edinburgh. …
Dr Annalisa Bettini
Annalisa is a research fellow at University College London. …
Dr Zhiping Feng
Zhiping is a research fellow at University College London. …
Identifying early response RNA binding proteins in cardiac fibrosis
The biomechanical stress associated with pathological heart extracellular matrix (ECM) remodelling modifies the transcriptional and post-transcriptional landscape of cardiac cells. Post-transcriptional events such as alternative splicing (AS), RNA …
Developing manganese-enhanced MRI as a translational biomarker of cardiac regeneration
Effective translation of the therapeutics developed in REACT will require in vivo monitoring of safety and efficacy. MRI, CT and ultrasound have been used to follow cardiac function in clinical and preclinical trials of cell therapies but have not been …