Screening for drivers of lymphangiogenesis
Myocardial infarction (MI) induces cardiac muscle death and its subsequent replacement by a non-contractile fibrotic scar, which leads to heart failure. Current treatments restore blood flow and assist with cardiac workload. However, none are regenerative …
Monitoring regenerative pathway activation in vivo
REACT will generate a range of therapies able to activate endogenous cardiac regeneration and cardiomyocyte proliferation. However, the lack of reliable in vivo methods for tracking cell cycle makes it challenging to study mechanisms and mediators of …
Modulating extracellular matrix composition to facilitate heart regeneration
After a heart attack (myocardial infarction, MI) the heart forms stiff scars made of collagen. These scars are stabilised by strong chemical bonds called cross-links, which make them hard to break down and hinder healing. Zebrafish hearts, unlike adult …
Mapping the heart proteome and lipidome
Heart disease is a complex condition that necessitates targeted drug delivery to specific cell types. To achieve this, a comprehensive understanding of the cell surface proteome and its receptor landscape is crucial. While RNA therapeutics hold immense …
Genetic tracing and topography of spontaneous and stimulated cardiac regeneration in mice
Ana Backovic …
CLIPPER Regulates LPIN1-Mediated Mitochondrial Biogenesis and Heart Regeneration
Francesco Paolo Ruberto …
Chordin-Like 1 mRNA Therapy for Acute Myocardial Infarction
Mateusz Tomczyk …
Pump-prime funding
Our pump-prime funding is intended to enable eligible researchers to carry out new projects that are highly innovative and may open new avenues of investigations towards the development of therapies for cardiac repair and regeneration. Projects must be …
Dr Beyza Güven
Beyza is a postdoctoral researcher at the University of Oxford. …