Target discovery
REACT members have pioneered the concept that small non-coding RNAs, mRNAs and cDNAs can be identified by screening and then administered to achieve cardiac regeneration. Therapeutic targets include stimulating cardiomyocyte proliferation, inducing the …
Using lipid nanoparticles to deliver small RNAs to the heart
Manendra Pachauri …
Dr Roman Fischer
Roman is an Associate Professor at the Target Discovery Institute and Centre for Medicines Discovery in the Nuffield Department of Medicine at the University of Oxford. Roman leads two proteomics-focussed laboratories: the Discovery Proteomics Facility …
Professor Ajay Shah
Ajay is BHF Chair of Cardiology and Executive Dean of the Faculty of Life Sciences & Medicine at King's College London, and an Honorary Consultant Cardiologist at King’s College Hospital. Ajay has a long-standing track record of innovative research in the …
Professor Mairi Brittan
Mairi is Professor of Cardiovascular Regeneration at the University of Edinburgh and co-investigator with REACT. Her area of expertise is using multimodal omics technology (single cell and nucleus RNA sequencing and spatial transcriptomics) to identify …
Dr Michael Weinberger
Michael started to work on heart development and repair when doing his PhD. Investigating the zebrafish, he characterised different cell populations in the epicardium, the outer cell layer of the heart. He went on to study the regulation of gene …
Dr Joaquim Nunes Vieira
Joaquim leads a research group at King’s College London focused on epicardial–vascular–stromal signalling in cardiac development and regeneration. His work uses preclinical and human models to study how the epicardium, the outer layer of the heart, …
Dr Alkystis Phinikaridou
Alkystis has expertise in the development and validation of molecular imaging probes that selectively bind to and report on tissue inflammatory activity and alterations in extracellular matrix proteins. In the context of heart failure, her team has …
Dr Abdelaziz Beqqali
Dr Abdelaziz (Appie) Beqqali is the REACT Chancellor's Fellow at the University of Edinburgh. Appie's research focuses on how RNA-binding proteins (RBPs) and alternative splicing regulate heart function and contribute to the development of heart failure. …
Dr Ian McCracken
As a BHF Immediate Fellow, Ian's research focuses on understanding how coronary blood vessel formation is controlled at the gene-expression level during both development and regeneration. In particular, he is interested in how the embryonic endocardium …