Organisation:
University of OxfordSpecialism:
Human model systems and organoidsChris is Associate Professor of Cardiovascular Science at the University of Oxford and Co-director of the Oxford Organoid Hub.
His group is interested in understanding changes in cellular function that are driven by acquired and inherited cardiomyopathies. They use human model systems including induced pluripotent stem cells and stem cell derived cardiac cells to model these diseases in the dish.
Chris has a particular interest in the use of more complex human 3D model systems such as organoids and microtissues to understand cellular interactions mimicking the heart that can be used to screen novel therapies. His group employ varied techniques to understand cellular function in live cells and model disease using CRISPR/Cas-9 in tandem with RNA sequencing and proteomics.
Chris is excited to provide expertise in human model systems to advance the goals of REACT, enabling screening and mechanism discovery in reductionist systems relevant to human disease.