Organisation:
King's College LondonSpecialism:
Cardiomyocyte proliferation, viral vectors, endogenous repairMauro is Professor of Cardiovascular Sciences and Head of the School of Cardiovascular and Metabolic Medicine & Sciences at King’s College London.
His current research interests focus on the development of nucleic acid therapeutics (RNA, AAV vectors) for cardiac repair, regeneration and gene editing. His laboratory has pioneered the concept that cardiac regeneration can be achieved through the simulation of endogenous cardiomyocyte proliferation using small non-coding RNAs. For cardioprotection, he has identified novel cytokines that stimulate protective autophagy and can be administered immediately after myocardial infarction.
To achieve precise gene editing, he is developing RNA-based treatments that stimulate homology-directed repair in cardiomyocytes and other post-mitotic cells.
Mauro is the founder of Forcefield Therapeutics and Heqet Therapeutics, two start ups that develop advanced therapies for myocardial infarction and heart failure.
